Mediators of Inflammation / 2015 / Article / Tab 1

Review Article

Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival

Table 1

Examples of miRNA downregulated in CVDs with potential connection on pyroptosis.

Human inflammasome component
(NCBI RefSeq)
miRNAs predicted by *TargetScan and reported to be downregulated in CVDsRelated CVDs [reference]

NLR proteins (NODs)
 NOD1 (NM_006092)miR-1DCM, AS [45], MI [46], LVH [47]
miR-133MI [46], LVH [47]
miR-208MI [46]
miR-499AS [45], MI [46]
 NOD2 (NM_022162)miR-30e-5pDCM, AS [45]
miR-208MI [46]
miR-499AS [45], MI [46]
 NOD3/NLRC3 (NM_178844)miR-10AS [45]
miR-24MI [59, 60]
 NOD4/NLRC5 (NM_032206)miR-21MI [61]
 NOD5/NLRX1 (NM_024618)miR-24MI [59, 60]
miR-133MI [46], LVH [47]
 CIITA (NM_000246)miR-10AS [45]
miR-24MI [59, 60]
NLR proteins (NOD-like receptor family pyrin domain containing, LNRPs)
 NLRP1 (NM_014922)miR-10AS [45]
 NLRP2 (NM_017852)No miRNA meets the screening criteria
 NLRP3 (NM_004895)miR-17-5pDCM [45]
miR-30e-5pDCM, AS [45]
 NLRP4 (NM_134444)No miRNA meets the screening criteria
 NLRP5 (NM_153447)No miRNA meets the screening criteria
 NLRP6Prediction data not available
 NLRP7 (NM_139176)miR-150MI [62]
 NLRP8 (NM_176811)miR-155MI [62], LVH [63]
 NLRP9 (NM_176820)miR-19DCM, AS [45]
 NLRP10Prediction data not available
 NLRP11 (NM_145007)No miRNA meets the screening criteria
 NLRP12 (NM_033297)No miRNA meets the screening criteria
 NLRP13Prediction data not available
 NLRP14 (NM_176822)miR-1DCM, AS [45], MI [46], LVH [47]
NLR proteins (ice protease-activating factor (IPAF))
 NLRC4 (NM_021209)No miRNA meets the screening criteria
 NAIP (NM_004536)miR-1DCM, AS [45], MI [46], LVH [47]
miR-24MI [59, 60]
miR-150MI [62]
Caspase
 Caspase-1 (NM_001223)No miRNA meets the screening criteria
Adaptor protein
 ASC/PYCARD (NM_013258)No miRNA meets the screening criteria

In TargetScan search, only the “miRNA families broadly conserved among vertebrates” for each of the target proteins were used to generate this table. DCM: dilated cardiomyopathy, AS: aortic stenosis, MI: myocardial infarction, and LVH: left ventricular hypertrophy.