Mediators of Inflammation / 2015 / Article / Tab 3

Review Article

Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival

Table 3

Selected examples of miRNAs targeting human negative regulators of pyroptosis and reported to be increased in CVDs.

Negative regulators of pyroptosis
(NCBI Refseq, reference)
miRNAs predicted by *TargetScan and reported to be upregulated in CVDsRelated CVDs [reference]

Autophagy
 ATG16L1
 (autophagy-related gene 16 like-1)
 (NM_017974, [52])
Let-7DCM, ICM, AS [45]
miR-125DCM [45, 64], AS [45], LVH [65]
miR-181DCM [64], AS [45]
miR-214DCM [45, 64], ICM, AS [45], LVH [65]
 MAP1LC3B
 (microtubule-associated proteins
 1A/1B light chain 3B)
 (NM_022818, [54])
miR-30e-5pDCM, AS [45]
miR-145AS [45]
miR-214DCM, ICM, AS [45], LVH [65, 66]
miR-221LVH [65]
miR-222DCM, ICM [45], LVH [65]
 BECN1 (Beclin1)
 (NM_003766, [54])
miR-30e-5pDCM, AS [45]
miR-199DCM, ICM [45], LVH [65, 66]
Transcription factors
 STAT1 (NM_007315, [56])miR-140DCM, ICM, AS [45], LVH [65]
miR-21LVH [65, 66]
miR-23DCM, ICM, AS [45], LVH [65, 66]
miR-24ICM, AS [45]
 FOXO3miR-27LVH [65, 66]
(NM_001455)miR-30dDiabetic cardiomyopathy [57]
*experimentally proven tomiR-99DCM, AS [45]
 be regulated by miR-30d [57]miR-103DCM, ICM, AS [45], LVH [65]
miR-125DCM, AS [45], LVH [65, 66]
miR-217LVH [66]
miR-221/222LVH [65]
NO synthase
 NOS2
  (inducible nitric oxide synthase)
miR-15DCM, AS [45]
  (NM_000625, [67])miR-214DCM [64], LVH [65, 66]

In TargetScan search, only the “miRNA families broadly conserved among vertebrates” for each of the target proteins were used to generate this table. DCM: dilated cardiomyopathy, AS: aortic stenosis, MI: myocardial infarction, and LVH: left ventricular hypertrophy.