Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival

Table 3

Selected examples of miRNAs targeting human negative regulators of pyroptosis and reported to be increased in CVDs.

Negative regulators of pyroptosis; (NCBI Refseq, reference)	miRNAs predicted by ^*TargetScan and reported to be upregulated in CVDs	Related CVDs [reference]
Autophagy
ATG16L1; (autophagy-related gene 16 like-1); (NM_017974, [52])	Let-7	DCM, ICM, AS [45]
	miR-125	DCM [45, 64], AS [45], LVH [65]
	miR-181	DCM [64], AS [45]
	miR-214	DCM [45, 64], ICM, AS [45], LVH [65]
MAP1LC3B; (microtubule-associated proteins; 1A/1B light chain 3B); (NM_022818, [54])	miR-30e-5p	DCM, AS [45]
	miR-145	AS [45]
	miR-214	DCM, ICM, AS [45], LVH [65, 66]
	miR-221	LVH [65]
	miR-222	DCM, ICM [45], LVH [65]
BECN1 (Beclin1); (NM_003766, [54])	miR-30e-5p	DCM, AS [45]
	miR-199	DCM, ICM [45], LVH [65, 66]
Transcription factors
STAT1 (NM_007315, [56])	miR-140	DCM, ICM, AS [45], LVH [65]
	miR-21	LVH [65, 66]
	miR-23	DCM, ICM, AS [45], LVH [65, 66]
	miR-24	ICM, AS [45]
FOXO3	miR-27	LVH [65, 66]
(NM_001455)	miR-30d	Diabetic cardiomyopathy [57]
^*experimentally proven to	miR-99	DCM, AS [45]
be regulated by miR-30d [57]	miR-103	DCM, ICM, AS [45], LVH [65]
	miR-125	DCM, AS [45], LVH [65, 66]
	miR-217	LVH [66]
	miR-221/222	LVH [65]
NO synthase
NOS2; (inducible nitric oxide synthase)	miR-15	DCM, AS [45]
(NM_000625, [67])	miR-214	DCM [64], LVH [65, 66]

In TargetScan search, only the “miRNA families broadly conserved among vertebrates” for each of the target proteins were used to generate this table. DCM: dilated cardiomyopathy, AS: aortic stenosis, MI: myocardial infarction, and LVH: left ventricular hypertrophy.