Review Article
Intracellular Cleavage of the Cx43 C-Terminal Domain by Matrix-Metalloproteases: A Novel Contributor to Inflammation?
Table 1
Results of cleavage site prediction based on SitePrediction
in silico analysis.
| | Matrix-metalloprotease | Position | Segment | Average score | Specificity |
| | MMP-2 | 357# | QPLA −/− IVDQ | 476.396 | >99% | | 355 | ELQP −/− LAIV | 117.022 | >99% | | 277 | PTAP −/− LSPM | 155.854 | >99% | | 254 | TSGA −/− LSPA | 106.264 | >99% | | 256 | ALSP −/− AKDC | 26.467 | >95% | | 326 | AGST −/− ISNS | 25.335 | >95% | | 252 | ATSG −/− ALSP | 22.937 | >95% | | 280 | PLSP −/− MSPP | 19.688 | >95% | | 379 | RPDD −/− LEI | 18.873 | >95% |
| | MMP-7 | 355 | ELQP −/− LAIV | 29.767 | >99% | | 287 | PGYK −/− LVTG | 29.767 | >99% | | 352 | AGHE −/− LQPL | 5.998 | >95% | | 255 | GALS −/− PAKD | 5.152 | >95% | | 277 | PTAP −/− LSPM | 4.057 | >95% | | 379 | RPDD −/− LEI | 3.397 | >95% | | 253 | TSGA −/− LSPS | 3.242 | >95% | | 285 | SPPG −/− YKLV | 2.469 | >95% | | 349 | KLAA −/− GHEL | 2.431 | >95% | | 238 | GVKD −/− RVKG | 2.119 | >95% |
| | MMP-9 | 285# | SPPG −/− YKLV | 47.023 | >99% | | 324 | GQAG −/− STIS | 35.498 | >99% | | 255 | GALS −/− PAKD | 13.580 | >95% | | 357# | QPLA −/− IVDQ | 11.443 | >95% | | 252 | ATSG −/− ALSP | 11.129 | >95% | | 235 | FFKG −/− VKDR | 4.991 | >95% |
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http://www.dmbr.ugent.be/prx/bioit2-public/SitePrediction/; #also identified by PROSPER.
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