Cellular Response upon Stress: p57 Contribution to the Final Outcome

Figure 1

Different mechanisms of transcriptional and posttranscriptional p57 regulation. (a) Imprinting control on the paternal allele; (b) long-range intrachromosomal interactions between p57 promoter and KvDMR1 can repress the transcriptional expression; (c) promoter demethylation, active histone marks, and transcriptional factors binding regulate p57 expression; (d) p57 mRNA stability is regulated by miR; (e) p57 protein stability is regulated by phosphorylation and ubiquitination.