Cellular Response upon Stress: p57 Contribution to the Final Outcome

Figure 2

Network of p57 pathways involved in the cellular response to stress. Schematic view of the different mechanisms by which p57 can modulate proliferation, apoptosis, and senescence. Green arrows indicate positive regulation; black T-bar arrows indicate negative regulation; black dotted arrows indicate translocation; red arrow indicates phosphorylation; black facing-down arrow indicates loss of mitochondrial transmembrane potential (ΔΨm).