Acute Respiratory Distress Syndrome: Role of Oleic Acid-Triggered Lung Injury and Inflammation

Figure 2

Intracellular pathways activated in oleic acid-induced lung injury and inflammation. Oleic acid triggers intracellular pathways through different receptors ending up in inflammatory mediator production and/or cell death. MAPK: mitogen-activated protein kinases, ERK1/2: extracellular signal-regulated kinases, NFκB: nuclear factor kappa-light-chain-enhancer of activated B cells, PI3K: phosphatidylinositol 3-kinase, AKT: protein kinase B, NLRC4: NLR family CARD domain-containing protein 4, MyD88: myeloid differentiation primary response gene 88, AP-1: activator protein 1, TLR: toll-like receptor, IL: interleukin, MIP: macrophage inflammatory protein, FFAR1: free fatty acid receptor 1, MCP1: monocyte chemotactic protein 1, TGFβ: transforming growth factor beta, and TNFα: tumor necrosis factor alpha.