Marine Diterpenoids as Potential Anti-Inflammatory Agents

Table 1

Anti-inflammatory effect of eunicellane diterpenoids.

	Families name	Biological source	COX-2	iNOS	Superoxide anion generation	Elastase release	Other
	Krempfielins	Cladiella krempfi		B-C, D [73]; E, G, I [77]		K, M [82]; N, P [84]
	Hirsutalins	C. hirsuta	B [71]	B-D, H [71]; K [78]		N [86]; S [87]
	Cladieunicellins	Cladiella sp.			C-E [80]; 6-epi F [81]	A, C-D [80]; 6-epi F [81]
	Klymollins	Klyxum molle	F-G [74]	C-H [74]	M [83]	M [83]	X [79]
	Klysimplexins	K. simplex	R-S [72]	J-N, R-S [75]
	Klysimplexin sulfoxides	K. simplex	C [72]	A-C [72]
	Simplexin	K. simplex	E [70]	A, D-E [70]

Data refer to compounds with percentage of inhibition > 50% for COX-2 and iNOS and >25% for superoxide anion generation and elastase release.
Percentage of inhibition 40–50%.