Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

Figure 1

Rats with tibia tumors after Walker 256 cells inoculation displayed mechanical allodynia. The PWT progressively decreased on days 5, 7, 10, 14, and 21 () after inoculation in BCP group compared with sham group. Results are given as means ± SEM. , versus sham group.