Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

Figure 4

Intrathecal administration of BD1047 suppressed the upregulation of c-Fos protein expression. (a) Compared with sham rats, the c-Fos expression was strikingly increased in BCP rats in the ipsilateral spinal cord on day 7. Intrathecal injection of BD1047 provided a significant decrease of the c-Fos in BCP rats compared with NS-treated BCP group. (b) Quantification of c-Fos level in the dorsal horn (). Results are given as means ± SEM. , versus sham + NS group; , versus BCP + NS group. Magnification: 100x.

(a)

(b)