Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

Figure 6

Spinal administration of BD1047 attenuated Iba-1 expression. (a) Immunohistochemistry data revealed that the expression of Iba-1 was significantly higher in BCP rats compared with sham rats in the ipsilateral spinal cord on day 7. Compared with NS-treated BCP group, BD1047-treated BCP group showed a striking decrease in the number of Iba-1 immunoreactive (IR) cells in the ipsilateral spinal cord. (b) Quantification of Iba-1 level in the dorsal horn (). Results are given as means ± SEM. , versus sham + NS group; , versus BCP + NS group. Magnification: 200x.

(a)

(b)