Mediators of Inflammation / 2015 / Article / Fig 1

Review Article

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation

Figure 1

Adherens junction-based cell adhesion requires a tight balance of tyrosine kinases and phosphatases. Oncogenic Src signaling and blockade of phosphatase activity, as well as complete inhibition of kinase activity, can lead to AJ disruption and loss of cell-cell adhesion.