Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

Figure 7

AS-IV inhibits LPS-induced NF-κB (a) and AP-1 (b) DNA-binding activity in mouse lung and heart. Mice were treated as described in the legend of Figure 2. Nuclear extracts were isolated from lung and heart. DNA-binding activity of NF-κB (p65) and AP-1 (c-fos) was quantified by ELISA. Data shown are means ± SEM of 5 animals per group. compared to animals treated with LPS only.

(a)

(b)