Mediators of Inflammation / 2015 / Article / Tab 2

Review Article

Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases

Table 2

GenesFunctions Expression in chronic liver diseases References

IL-1It activates T and B cells and monocytes Up[123, 132, 135, 138]
IL-2It is necessary for the growth, proliferation, and differentiation of thymic-derived lymphocytes (T cells)Up, down[133]
IL-4It induces secretion of Ig by B cells, pleiotropic effect on T cellsUp[123]
IL-6It is an important mediator of fever and of the acute phase response and stimulates thymocyte proliferation and fibroblast growth factor activityUp[137, 139]
IL-8It acts as neutrophil chemotactic factor and can induce chemotaxis in target cells, primarily neutrophils, and also other granulocytes, causing them to migrate toward the site of infectionUp[120, 128, 134]
IL-10It stimulates proliferation of B cells, thymocytes, and mast cells, stimulates IgA production by B cells, and also enhances B cell survivalUp, down[123, 124, 138]
JunIt is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignanciesUp[124]
NF-BUpon activation of either T or B cell receptor, it upregulates genes involved in T cell development, maturation, and proliferationUp[130]
TGF-It suppresses T cell growth and differentiationUp, down[121, 139]
TNF-It is an adipokine involved in systemic inflammation, is a member of a group of cytokines that stimulate the acute phase reaction, and is a mediator of immune functions in the regulation of immune cellsUp, down[140]