Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2015, Article ID 278785, 7 pages
http://dx.doi.org/10.1155/2015/278785
Research Article

Presence of Fatty Liver and the Relationship between Alcohol Consumption and Markers of Inflammation

1Department of Internal Medicine II (Cardiology, Angiology, Pulmonology, Sports, and Rehabilitation Medicine), University of Ulm Medical Centre, Albert-Einstein-Allee 23, 89081 Ulm, Germany
2Department of Internal Medicine I (Gastroenterology, Endocrinology, and Nephrology), University of Ulm Medical Centre, Albert-Einstein-Allee 23, 89081 Ulm, Germany

Received 8 December 2014; Accepted 2 February 2015

Academic Editor: Jan G. C. van Amsterdam

Copyright © 2015 Martin Kächele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Bedogni, L. Miglioli, F. Masutti, C. Tiribelli, G. Marchesini, and S. Bellentani, “Prevalence of and risk factors for nonalcoholic fatty liver disease: the dionysos nutrition and liver study,” Hepatology, vol. 42, no. 1, pp. 44–52, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. L. S. Bhatia, N. P. Curzen, P. C. Calder, and C. D. Byrne, “Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?” European Heart Journal, vol. 33, no. 10, pp. 1190–1200, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Libby, P. M. Ridker, and G. K. Hansson, “Progress and challenges in translating the biology of atherosclerosis,” Nature, vol. 473, no. 7347, pp. 317–325, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Bayard, J. Holt, and E. Boroughs, “Nonalcoholic fatty liver disease,” The American Family Physician, vol. 73, no. 11, pp. 1961–1968, 2006. View at Google Scholar
  5. P. Loria, A. Lonardo, S. Bellentani, C. P. Day, G. Marchesini, and N. Carulli, “Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 17, no. 9, pp. 684–698, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Braunersreuther, G. L. Viviani, F. Mach, and F. Montecucco, “Role of cytokines and chemokines in non-alcoholic fatty liver disease,” World Journal of Gastroenterology, vol. 18, no. 8, pp. 727–735, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Koenig and N. Khuseyinova, “Biomarkers of atherosclerotic plaque instability and rupture,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 1, pp. 15–26, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Gaziano, T. A. Gaziano, R. J. Glynn et al., “Light-to-moderate alcohol consumption and mortality in the physicians' health study enrollment cohort,” Journal of the American College of Cardiology, vol. 35, no. 1, pp. 96–105, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. U. Keil, L. E. Chambless, A. Döring, B. Filipiak, and J. Stieber, “The relation of alcohol intake to coronary heart disease and all-cause mortality in a beer-drinking population,” Epidemiology, vol. 8, no. 2, pp. 150–156, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. I. R. White, “The level of alcohol consumption at which all-cause mortality is least,” Journal of Clinical Epidemiology, vol. 52, no. 10, pp. 967–975, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Costanzo, A. di Castelnuovo, M. B. Donati, L. Iacoviello, and G. de Gaetano, “Alcohol consumption and mortality in patients with cardiovascular disease: a meta-analysis,” Journal of the American College of Cardiology, vol. 55, no. 13, pp. 1339–1347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Imhof, M. Froehlich, H. Brenner, H. Boeing, M. B. Pepys, and W. Koenig, “Effect of alcohol consumption on systemic markers of inflammation,” The Lancet, vol. 357, no. 9258, pp. 763–767, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. S. E. Brien, P. E. Ronksley, B. J. Turner, K. J. Mukamal, and W. A. Ghali, “Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies,” British Medical Journal, vol. 342, article d636, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Imhof and W. Koenig, “Alcohol inflammation and coronary heart disease,” Addiction Biology, vol. 8, no. 3, pp. 271–277, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. Albert, R. J. Glynn, and P. M. Ridker, “Alcohol consumption and plasma concentration of C-reactive protein,” Circulation, vol. 107, no. 3, pp. 443–447, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Brea, D. Mosquera, E. Martín, A. Arizti, J. L. Cordero, and E. Ros, “Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 5, pp. 1045–1050, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Akabame, M. Hamaguchi, K.-I. Tomiyasu et al., “Evaluation of vulnerable coronary plaques and non-alcoholic fatty liver disease (NAFLD) by 64-detector multislice computed tomography (MSCT),” Circulation Journal, vol. 72, no. 4, pp. 618–625, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Targher, L. Bertolini, R. Padovani et al., “Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease,” Diabetes Care, vol. 29, no. 6, pp. 1325–1330, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Meisinger, J. Baumert, N. Khuseyinova, H. Loewel, and W. Koenig, “Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population,” Circulation, vol. 112, no. 5, pp. 651–657, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. P. M. Ridker, N. Rifai, L. Rose, J. E. Buring, and N. R. Cook, “Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events,” The New England Journal of Medicine, vol. 347, no. 20, pp. 1557–1565, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. P. M. Ridker, N. Rifai, M. J. Stampfer, and C. H. Hennekens, “Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men,” Circulation, vol. 101, no. 15, pp. 1767–1772, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. S.-J. Hwang, C. M. Ballantyne, A. R. Sharrett et al., “Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases. The Atherosclerosis Risk in Communities (ARIC) study,” Circulation, vol. 96, no. 12, pp. 4219–4225, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Imhof, M. Woodward, A. Doering et al., “Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille),” European Heart Journal, vol. 25, no. 23, pp. 2092–2100, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. M. Haenle, S. O. Brockmann, M. Kron et al., “Overweight, physical activity, tobacco and alcohol consumption in a cross-sectional random sample of German adults,” BMC Public Health, vol. 6, article 233, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. S. H. Saverymuttu, A. E. A. Joseph, and J. D. Maxwell, “Ultrasound scanning in the detection of hepatic fibrosis and steatosis,” British Medical Journal, vol. 292, no. 6512, pp. 13–15, 1986. View at Publisher · View at Google Scholar · View at Scopus
  26. A. E. A. Joseph, S. H. Saverymuttu, S. Al-Sam, M. G. Cook, and J. D. Maxwell, “Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease,” Clinical Radiology, vol. 43, no. 1, pp. 26–31, 1991. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Dunn, R. Xu, and J. B. Schwimmer, “Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease,” Hepatology, vol. 47, no. 6, pp. 1947–1954, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. W. Dunn, A. J. Sanyal, E. M. Brunt et al., “Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD),” Journal of Hepatology, vol. 57, no. 2, pp. 384–391, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. H. P. Cotrim, L. A. Freitas, E. Alves, A. Almeida, D. S. May, and S. Caldwell, “Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients,” European Journal of Gastroenterology and Hepatology, vol. 21, no. 9, pp. 969–972, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. O. Turgut and I. Tandogan, “Gamma-glutamyltransferase to determine cardiovascular risk: shifting the paradigm forward,” Journal of Atherosclerosis and Thrombosis, vol. 18, no. 3, pp. 177–181, 2011. View at Publisher · View at Google Scholar · View at Scopus