Presence of Fatty Liver and the Relationship between Alcohol Consumption and Markers of Inflammation
Table 3
Concentrations of inflammatory markers, according to alcohol consumption (arithmetic or geometric* mean with 95% confidence intervals, for difference between categories).
Alcohol intake in [g/day]
Fatty liver
0
0–20
>20–40
>40–60
>60
(%) Yes/no
35/65
19/81
34/66
32/51
22/27
CRP* mg/L
Total
1.30 (1.03–1.64)
1.09 (0.87–1.38)
0.97 (0.77–1.22)
1.06 (0.82–1.37)
1.09 (0.79–1.52)
0.51
Yes
1.55 (0.7–2.0)
2.76 (1.1–4.5)
1.50 (1.0–2.3)
1.44 (0.9–1.9)
2.25 (0.8–2.8)
0.001
No
0.89 (0.3–1.3)
0.86 (0.1–1.1)
0.85 (0.2–1.2)
1.00 (0.3–1.3)
0.82 (0.1–1.4)
0.0002
Fibrinogen g/L
Total
3.33 (0.83)
3.07 (0.74)
3.04 (0.78)
3.07 (0.73)
3.12 (0.92)
0.072
Yes
3.36 (3.1–3.6)
3.32 (3.1–3.5)
3.37 (3.1–3.6)
3.19 (3.0–3.4)
3.53 (3.1–3.8)
0.04
No
3.12 (2.9–3.3)
2.96 (2.8–3.1)
2.93 (2.7–3.0)
3.11 (2.9–3.3)
3.03 (2.7–3.2)
<0.0001
oxLDL U/mL
Total
63.51 (22.0)
60.63 (20.7)
65.71 (20.4)
64.73 (20.1)
64.74 (19.4)
0.48
Yes
67.5 (60–77)
76.2 (68–87)
76.5 (69–82)
73.3 (65–80)
72.8 (63–79)
0.16
No
62.9 (56–68)
56.6 (52–62)
57.9 (53–62)
60.2 (55–65)
57.7 (51–65)
<0.0001
Adiponectin g/mL
Total
7.70 (4.91)
9.22 (5.46)
7.26 (3.86)
8.24 (4.65)
6.42 (3.79)
0.0046
Yes
5.04 (4.1–5.9)
7.74 (7.0–8.6)
6.20 (5.4–7.0)
7.02 (6.0–7.7)
6.54 (5.8–7.4)
<0.0001
No
7.59 (6.8–8.5)
8.91 (8.2–9.6)
8.48 (7.7–9.2)
9.86 (9.1–10.6)
8.07 (7.4–8.6)
<0.0001
IL-6* pg/mL
Total
1.52 (1.32–1.74)
1.41 (1.22–1.61)
1.37 (1.19–1.57)
1.58 (1.36–1.84)
1.75 (1.44–2.14)
0.2405
Yes
1.85 (1.1–2.4)
2.02 (1.4–3.2)
1.63 (1.1–2.0)
1.98 (1.0–2.8)
2.32 (1.4–3.3)
0.08
No
1.25 (0.5–1.5)
1.35 (0.4–1.7)
1.24 (0.4–1.6)
1.33 (0.6–1.9)
1.64 (0.8–2.2)
<0.0001
E-selectin ng/mL
Total
32.7 (13.4)
32.94 (12.3)
36.39 (14.4)
37.50 (15.5)
40.62 (16.4)
0.0041
Yes
41.3 (36–46)
40.9 (37–44)
39.8 (36–45)
40.8 (37–46)
42.3 (38–47)
0.09
No
30.2 (27–34)
31.8 (29–35)
35.3 (31–38)
33.3 (29–37)
35.4 (29–40)
0.003
Adjusted for age, gender, BMI, smoking, physical inactivity, education, and HDL-cholesterol; ex-drinkers excluded.
