Research Article
Elevated Serum Levels of Soluble TNF Receptors and Adhesion Molecules Are Associated with Diabetic Retinopathy in Patients with Type-1 Diabetes
Table 2
Multivariate logistic regression analysis for proteins after adjustment for age, sex, and disease duration.
| | | Model 1 | Model 2 | Model 3 | Model 4 | | | OR (CI 95%) | OR (CI 95%) | OR (CI 95%) | OR (CI 95%) | | | value | value | value | value |
| | sTNFR-I | 1.83 (1.49–2.28) | 1.62 (1.31–2.02) | 1.67 (1.35–2.09) | 1.57 (1.25–2.00) | | 2.67 × 10−8 | 3.24 × 10−9 | 4.00 × 10−6 | 1.66 × 10−4 | | sTNFR-II | 1.54 (1.24–1.97) | 1.32 (1.09–1.64) | 1.32 (1.09–1.64) | 1.18 (0.97–1.46) | | 2.46 × 10−4 | 7.44 × 10−3 | 7.67 × 10−3 | 0.113 | | CRP | 1.16 (1.06–1.27) | 1.16 (1.06–1.28) | 1.16 (1.05–1.28) | 1.15 (1.04–1.29) | | 1.51 × 10−3 | 2.68 × 10−3 | 4.07 × 10−3 | 9.37 × 10−3 | | SAA | 1.10 (1.01–1.19) | 1.07 (0.98–1.16) | 1.06 (0.97–1.16) | 1.10 (1.00–1.22) | | 0.025 | 0.145 | 0.200 | 0.046 | | sgp130 | 1.59 (1.21–2.14) | 1.58 (1.18–2.15) | 1.58 (1.19–2.16) | 1.43 (1.05–1.97) | | 1.61 × 10−3 | 2.71 × 10−3 | 2.71 × 10−3 | 0.026 | | sIL6R | 1.26 (1.00–1.63) | 1.27 (0.99–1.69) | 1.28 (1.00–1.70) | 1.25 (0.96–1.66) | | 0.069 | 0.077 | 0.070 | 0.108 | | sVCAM1 | 1.30 (1.05–1.64) | 1.28 (1.01–1.63) | 1.28 (1.01–1.63) | 1.27 (0.98–1.65) | | 0.021 | 0.044 | 0.046 | 0.074 | | sICAM1 | 1.59 (1.25–2.04) | 1.56 (1.20–2.03) | 1.54 (1.19–2.01) | 1.42 (1.07–1.89) | | 1.65 × 10−4 | 8.6 × 10−4 | 1.08 × 10−3 | 0.015 |
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Model 1: no adjustments, model 2: adjusted for age, model 3: adjusted for age and sex, and model 4: adjusted for age, sex, and T1D duration.
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