Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE₂ Cascade

Table 1

Morphological changes of cisplatin-induced renal injury in control, cisplatin vehicle, and cisplatin + OA-NO₂ mice as assessed by histological analysis.

Changes	Groups
	Cont.	Cisplatin	Cisplatin + OA-NO2
Glomerular congestion	—	++	+
Glomerular atrophy	—	++	+
Cast	—	+++	+
Tubular brush border loss	—	++	+
Tubular necrosis	—	++	+
Tubular atrophy	—	+++	+
Interstitial inflammation	—	+++	+

Scoring scalescores (none (—); mild damage (+);  moderate damage (++); and severe damage (+++)) are semiquantitative scores given by a pathologist unaware of the type of treatment.