Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial

Figure 7

Nutrigenomic networking. Network showing upregulation (solid arrows) and downregulation (dashed arrows) of genes involved in inflammation, oxidative stress, and drug metabolism, in comparison with (a) baseline versus McD, (b) baseline versus NPVRW, (c) baseline versus McD + NPVRW, and (d) McD versus McD + NPVRW. Filled circle indicates upregulation in response to treatment; dashed circle indicates downregulation in response to treatment; empty circle indicates not significant genes. Oxidative stress genes: CAT, Catalase (NM_1752); GPX1, Glutathione Peroxidase 1 (NM_581); GPX2, Glutathione Peroxidase 1 (gastrointestinal) (NM_2083); UCP2, Uncoupling Protein 2 (Mitochondrial Proton Carrier) (NM_3355); SOD 1, Superoxide Dismutase 1 Soluble (NM_454); NOX4, Nadph. Oxidase 4 (NM_16931); ALB, Albumin (NM_477); CCL5, Copper Chaperone for Superoxide Dismutase (NM_2985). Inflammasome genes: CASP8, Caspase 1 Apoptosis Related Cysteine Peptidase (NM_1228); NFKB1, Nuclear Factor of Kappa Light Polypeptides Gene Enhancer in B-Cells 1 (NM_3998); CCL2, Chemokine (C-C motif) Ligand 2 (NM_2982); PYCARD, Pyd and Card Domain Containing (NM_13258); RPLP0, Ribosomal Protein Large P0 (NM_1002); NLRP12, Nrl Family Pyrin Domain Containing 12 (NM_33297); IL 6, Interleukin 6 (Interferon Beta 2) (NM_600). Human Drug Metabolism genes: NAT1, N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NM_662); NOS3, Nitric Oxide Synthase 3 (Endothelial Cell) (NM_603); APOE, Apolipoprotein E (NM_41); ADH4, Alcohol Dehydrogenase 4-Class 2 Pi Polypeptide (NM_670); ALOX15, Arachidonate 15-Lipoxygenase (NM_1140); ALOX5, Arachidonate 5-Lipoxygenase (NM_698); HSD17 B2, Hydroxysteroid (17 Beta) Dehydrogenase 2 (NM_2153); ALDH1A1, Aldehyde Dehydrogenase 1 Family Member A1 (NM_689); MT2A, Metallothionein 2a (NM_5953).

(a) Baseline versus McDM

(b) Baseline versus NPVRW

(c) Baseline versus McDM + NPVRW

(d) McDM versus McDM + NPVRW