Disturbances of Modulating Molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA Expressions in the Orbital Tissue from Patients with Severe Graves’ Ophthalmopathy

Figure 3

(a) Quantitative RT-PCR validation of the mRNA expression changes for the CD86/CD28/CTLA-4: FOXP3 and CD40/CD40L molecules in GO (mild + severe) orbital tissues compared to control tissue samples. The values above “1.0” on the -axis show the relative higher expression in GO versus control samples and values below “1.0” indicate relatively lower expression. (b) The individual data from RT-PCR displaying the expression of mRNA for transcription factor FoxP3 in control and examined (GO) samples (medians and 25th–75th percentiles) ().

(a)

(b)