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Mediators of Inflammation
Volume 2015, Article ID 347965, 16 pages
Research Article

Sustained Interleukin-1β Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids

1Department of Medicine, School of Medicine, Alcala University (UAH), Alcalá de Henares, 28805 Madrid, Spain
2Biologie des Bactéries Intracellulaires, Departement Genomes et Génétique, Institut Pasteur, 75015 Paris, France
3Immunology and Individualized Medicine, IMMPA CSIC/UAH Joint Unit, Alcalá de Henares, 28805 Madrid, Spain
4MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London, Division of Asthma, Allergy & Lung Biology, 5th Floor Tower Wing, Guy’s Hospital, London SE1 9RT, UK
5Department of Immunology and Oncology, National Biotechnology Center, Spanish National Research Council (CNB-CSIC), 28049 Madrid, Spain

Received 10 December 2014; Revised 22 February 2015; Accepted 26 February 2015

Academic Editor: Tânia Silvia Fröde

Copyright © 2015 Pedro Escoll et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material contains nine supplementary figures that provide access to essential data that do not appear in the main article but that are complementary to the experiments reported in the final paper and required to reach all the final conclusions. These data are peer-reviewed and are subject to the same criteria as data in the main article.

  1. Supplementary Material