Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension

Figure 2

The expression ratio (ratio of the mean in the IPH group to the mean in the healthy control group) was calculated for each gene. Results of functional annotation clustering analysis are given for (a) the group showing significantly reduced expression among patients with IPH (Group C: healthy control/IPH > 1.5, ) and (b) the group showing significantly increased expression among patients with IPH (Group D: IPH/healthy control > 1.5, ). (a) Group C had the highest enrichment score (3.37), and its cluster included many gene terms related to the immune system, such as “lymphocyte activation” and “leukocyte activation.” (b) In Group D, the enrichment score was low (0.94), and no gene function terms were found to be specifically increased in the presence of IPH.

(a)

(b)