Mediators of Inflammation / 2015 / Article / Tab 2

Research Article

Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension

Table 2

Top 25 canonical pathways associated with IPH in Ingenuity iReport.

NumberPathwaysDEGs valueGenes

1Primary immunodeficiency signaling40.000120085ADA, CD79A, IGHD, IGLL1/IGLL5
2Altered T-cell and B-cell signaling in rheumatoid arthritis40.000772903CD28, SLAMF1, TGFB1, CD79A
3T-helper cell differentiation30.004440048CD28, TGFB1, TNFRSF11B
4Cyclins and cell cycle regulation30.006251755TGFB1, CDK7, E2F5
5B-cell development20.010284999CD79A, IGHD
6Leukocyte extravasation signaling40.013183985CXCR4, CD44, MLLT4, MMP12
7Atherosclerosis signaling30.019146088TGFB1, CXCR4, PLA2G10
8Arachidonic acid metabolism30.021798453GPX3, PLA2G10, CYP4F3
9Colorectal cancer metastasis signaling40.027547337RHOQ, TGFB1, PTGER2, MMP12
10Aryl hydrocarbon receptor signaling30.028201448TGFB1, NFIA, GSTA5
11Hepatic fibrosis/hepatic stellate cell activation30.029806364TGFB1, EDNRA, TNFRSF11B
12Glioma invasiveness signaling20.030646264RHOQ, CD44
13Glutathione metabolism20.031643803GPX3, GSTA5
14Cell cycle: G1/S checkpoint regulation20.03367696TGFB1, E2F5
15Eicosanoid signaling20.03367696PLA2G10, PTGER2
16Induction of apoptosis by HIV120.03367696CXCR4, TNFRSF11B
17Hypoxia signaling in the cardiovascular system20.037891658UBE2D2, HIF1AN
18Tight junction signaling30.038540606TGFB1, MLLT4, TNFRSF11B
19Germ cell-sertoli cell junction signaling30.039164578RHOQ, TGFB1, MLLT4
20Mitotic roles of Polo-like kinase20.040070987TGFB1, PTTG1
21Purine metabolism40.043235613ENTPD4, ABCC1, ADA, SEPT1
22Endothelin-1 signaling30.046366635PLA2G10, EDNRA, PTGER2
23Regulation of IL-2 expression in activated and anergic T Lymphocytes20.05532422CD28, TGFB1
24Chronic myeloid leukemia signaling20.073630475TGFB1, E2F5
25HMGB1 signaling20.075004378RHOQ, TNFRSF11B

Underlined genes indicate increases in expression. Not underlined genes indicate decreases in expression.
DEGs: differentially expressed genes.