Mediators of Inflammation

Research Article

Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension

Table 3

Top 25 biological processes associated with IPH in Ingenuity iReport.


Number	Biological process	DEGs	value	Genes

1	Synthesis of leukotriene B4	4		TGFB1, ABCC1, ADA, PTGER2
2	Synthesis of leukotriene	5		TGFB1, PLA2G10, ABCC1, ADA, PTGER2
3	Quantity of pro-B lymphocytes	5		CD28, CXCR4, CD79A, IGLL1/IGLL5, TNFRSF11B
4	T-cell migration	8		CD28, TGFB1, CXCR4, GNLY, RASGRP1, PLA2G10, ABCC1, CD44
5	Arrest in cell cycle progression of keratinocyte cancer cell lines	2		TGFB1, MELK
6	Function of leukocytes	12		CD28, SLAMF1, TGFB1, CXCR4, RASGRP1, PLA2G10, ABCC1, ADA, CD44, PTGER2, MMP12, LAX1
7	Transcytosis of HIV-1	2		CXCR4, CD79A
8	Cell movement of hairy leukemia cells	2		TGFB1, CD44
9	Invasion of keratinocyte cancer cell lines	2		TGFB1, PTGER2
10	Signaling of T lymphocytes	3		CD28, SLAMF1, CD44
11	Metabolism of eicosanoid	7	0.000109678	TGFB1, PLA2G10, ABCC1, ADA, CYP4F3, EDNRA, PTGER2
12	Reorganization of membrane rafts	2	0.000135709	CD28, CD44
13	Response of memory T lymphocytes	2	0.000135709	CD28, TGFB1
14	Fusion of leukocytes	3	0.000153367	CXCR4, CD44, TNFRSF11B
15	Lymphopoiesis of cells	3	0.000153367	TGFB1, CXCR4, CD44
16	Migration of mammary tumor cells	3	0.000153367	TGFB1, CXCR4, CD44
17	Cell viability of leukocytes	7	0.000162768	CD28, TGFB1, CXCR4, CD44, LAX1, CD79A, TNFRSF11B
18	Transmigration of mononuclear leukocytes	4	0.000170867	CD28, TGFB1, CXCR4, CD44
19	Lymphopoiesis	4	0.000182632	TGFB1, CXCR4, CD44, IGLL1/IGLL5
20	Adhesion of prostate cancer cell lines	3	0.000200182	TGFB1, CXCR4, CD44
21	Invasion of breast cell lines	3	0.000200182	TGFB1, CXCR4, PTGER2
22	TH1 immune response of naive T lymphocytes	2	0.000225478	CD28, TGFB1
23	Adhesion of hyaluronic acid	2	0.000225478	TGFB1, CD44
24	Morphology of cardiovascular tissue	4	0.000235591	TGFB1, CXCR4, CD44, TNFRSF11B
25	Migration of tumor cell lines	10	0.000252381	TNFAIP8, TGFB1, CXCR4, RASGRP1, CDK7, PTTG1, SERPINA5, CD44, E2F5, MLLT4

Underlined genes indicate increases in expression. Not underlined genes indicate decreases in expression.
DEGs: differentially expressed genes.