Caffeine Mitigates Lung Inflammation Induced by Ischemia-Reperfusion of Lower Limbs in Rats

Figure 4

The pulmonary malondialdehyde (MDA) concentrations. Sham: the sham-operation group. Sham + Caf: the sham plus caffeine group. IR: the lower limb ischemia-reperfusion group. IR + Caf: the IR plus caffeine group. Rats of the Sham + Caf and the IR + Caf groups received caffeine (50 mg/kg, intraperitoneal injection) immediately after reperfusion. To control for the effects of treatment vehicle, rats of the Sham and the IR group received normal saline (1.0 mL, intra-peritoneal injection) at the comparable time point. One-way analysis of variance with the Bonferroni-Dunn test was used for multiple comparisons. The significance level was set at 0.05. Data were derived from 6 rats from each group and presented as mean ± standard deviation. : the IR group versus the Sham group. : the IR + Caf group versus the IR group.