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Mediators of Inflammation
Volume 2015, Article ID 362126, 11 pages
http://dx.doi.org/10.1155/2015/362126
Research Article

Cannabinoid Receptor CB2 Is Involved in Tetrahydrocannabinol-Induced Anti-Inflammation against Lipopolysaccharide in MG-63 Cells

Lei Yang,1,2 Fei-Fei Li,1 Yu-Chen Han,1 Bin Jia,3 and Yin Ding1

1State Key Laboratory of Military Stomatology, Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
2Department of Stomatology, The 264th Hospital of PLA, Taiyuan, Shanxi 030001, China
3Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China

Received 21 November 2014; Revised 22 December 2014; Accepted 24 December 2014

Academic Editor: Fulvio D’Acquisto

Copyright © 2015 Lei Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Sun, B. Zhang, L. Chen, and J. Sun, “Role of nuclear factor of activated T cells 1 in the pathogenesis of osteoarthritis,” Experimental and Therapeutic Medicine, vol. 7, no. 1, pp. 195–198, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. X. Liu, Y. Xu, S. Chen et al., “Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases,” Free Radical Biology and Medicine, vol. 68, pp. 234–246, 2014. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. M. A. Karsdal, A. C. Bay-Jensen, R. J. Lories et al., “The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?” Annals of the Rheumatic Diseases, vol. 73, no. 2, pp. 336–348, 2014. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. S. Yang, C. E. Dubé, C. B. Eaton, T. E. McAlindon, and K. L. Lapane, “Longitudinal use of complementary and alternative medicine among older adults with radiographic knee osteoarthritis,” Clinical Therapeutics, vol. 35, no. 11, pp. 1690–1702, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. Y. Tu, H. Xue, W. Francis et al., “Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3,” Biochemical and Biophysical Research Communications, vol. 441, no. 1, pp. 249–255, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. L. Gallelli, O. Galasso, D. Falcone et al., “The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial,” Osteoarthritis and Cartilage, vol. 21, no. 9, pp. 1400–1408, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. A. Lanas, J. L. Goldstein, F. K. L. Chan et al., “Risk factors associated with a decrease ≥2 g/dL in haemoglobin and/or ≥10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR),” Alimentary Pharmacology and Therapeutics, vol. 36, no. 5, pp. 485–492, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. R. Chen, J. Zhang, N. Fan et al., “Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling,” Cell, vol. 155, no. 5, pp. 1154–1165, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. I. G. Otterness, M.-P. H. Le Graverand, and F. Eckstein, “Allometric relationships between knee cartilage volume, thickness, surface area and body dimensions,” Osteoarthritis and Cartilage, vol. 16, no. 1, pp. 34–40, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. D. Kleinloog, J. Stevens, J. Heuberger, P. Spinhoven, and J. van Gerven, “The influence of personality on the sensitivity to subjective effects of Δ9-tetrahydrocannabinol,” Psychiatry Research, vol. 220, no. 3, pp. 945–953, 2014. View at Publisher · View at Google Scholar · View at PubMed
  11. W. B. Veldhuis, M. van der Stelt, M. W. Wadman et al., “Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases,” The Journal of Neuroscience, vol. 23, no. 10, pp. 4127–4133, 2003. View at Google Scholar · View at Scopus
  12. W. Wang, R. Eddy, and J. Condeelis, “The cofilin pathway in breast cancer invasion and metastasis,” Nature Reviews Cancer, vol. 7, no. 6, pp. 429–440, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. W.-J. Ma, X. Guo, J.-T. Liu et al., “Proteomic changes in articular cartilage of human endemic osteoarthritis in China,” Proteomics, vol. 11, no. 14, pp. 2881–2890, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. N. Chiang, J. M. Schwab, G. Fredman, K. Kasuga, S. Gelman, and C. N. Serhan, “Anesthetics impact the resolution of inflammation,” PLoS ONE, vol. 3, no. 4, Article ID e1879, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. J. Rüegg, F. Holsboer, C. Turck, and T. Rein, “Cofilin 1 is revealed as an inhibitor of glucocorticoid receptor by analysis of hormone-resistant cells,” Molecular and Cellular Biology, vol. 24, no. 21, pp. 9371–9382, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. F. Fazal, K. M. Bijli, M. Minhajuddin, T. Rein, J. N. Finkelstein, and A. Rahman, “Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells,” Journal of Biological Chemistry, vol. 284, no. 31, pp. 21047–21056, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. M. M. Kim, E. Mendis, N. Rajapakse, and S.-K. Kim, “Glucosamine sulfate promotes osteoblastic differentiation of MG-63 cells via anti-inflammatory effect,” Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 7, pp. 1938–1942, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. X. Xu, J. A. Kim, and Z. Zuo, “Isoflurane preconditioning reduces mouse microglial activation and injury induced by lipopolysaccharide and interferon-gamma,” Neuroscience, vol. 154, no. 3, pp. 1002–1008, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. T. H. Huang, Y. C. Lu, and C. T. Kao, “Low-level diode laser therapy reduces lipopolysaccharide (LPS)-induced bone cell inflammation,” Lasers in Medical Science, vol. 27, no. 3, pp. 621–627, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. J. D. Leu, Y. W. Chiu, C. C. Lo et al., “Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity,” International Journal of Radiation Biology, vol. 89, no. 6, pp. 433–444, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. Y.-J. Lee, T.-J. Sheu, and P. C. Keng, “Enhancement of radiosensitivity in H1299 cancer cells by actin-associated protein cofilin,” Biochemical and Biophysical Research Communications, vol. 335, no. 2, pp. 286–291, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. S. Hashimoto, R. L. Ochs, S. Komiya, and M. Lotz, “Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis,” Arthritis & Rheumatism—Arthritis Care & Research, vol. 41, no. 9, pp. 1632–1638, 1998. View at Google Scholar
  23. C. T. Hepper, J. J. Halvorson, S. T. Duncan, A. J. M. Gregory, W. R. Dunn, and K. P. Spindler, “The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies,” Journal of the American Academy of Orthopaedic Surgeons, vol. 17, no. 10, pp. 638–646, 2009. View at Google Scholar · View at Scopus
  24. L. Gallelli, O. Galasso, D. Falcone et al., “The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial,” Osteoarthritis and Cartilage, vol. 21, no. 9, pp. 1400–1408, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. A. Pareek and N. Chandurkar, “Comparison of gastrointestinal safety and tolerability of aceclofenac with diclofenac: a multicenter, randomized, double-blind study in patients with knee osteoarthritis,” Current Medical Research & Opinion, vol. 29, no. 7, pp. 849–859, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. D. Bolognini, B. Costa, S. Maione et al., “The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice,” British Journal of Pharmacology, vol. 160, no. 3, pp. 677–687, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. N. Egashira, N. Manome, K. Mishima, K. Iwasaki, R. Oishi, and M. Fujiwara, “Involvement of opioid system in cognitive deficits induced by Δ9-tetrahydrocannabinol in rats,” Psychopharmacology, vol. 219, no. 4, pp. 1111–1118, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. Q. Li, H. C. Guo, L. N. Maslov, X. W. Qiao, J. J. Zhou, and Y. Zhang, “Mitochondrial permeability transition pore plays a role in the cardioprotection of CB2 receptor against ischemia-reperfusion injury,” Canadian Journal of Physiology and Pharmacology, vol. 92, no. 3, pp. 205–214, 2014. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. S. Locatelli-Hoops, F. C. Sheen, L. Zoubak, K. Gawrisch, and A. A. Yeliseev, “Application of HaloTag technology to expression and purification of cannabinoid receptor CB2,” Protein Expression and Purification, vol. 89, no. 1, pp. 62–72, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. D. V. Gondim, J. C. B. Araújo, A. L. C. Cavalcante et al., “CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of electroacupuncture on experimental arthritis of the rat temporomandibular joint,” Canadian Journal of Physiology and Pharmacology, vol. 90, no. 11, pp. 1479–1489, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. J. G. Zarruk, D. Fernández-López, I. García-Yébenes et al., “Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection,” Stroke, vol. 43, no. 1, pp. 211–219, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. C. A. Newton and T. W. Klein, “Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice,” Journal of Neuroimmune Pharmacology, vol. 7, no. 3, pp. 591–598, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. T. Kawano, M. Zhu, N. Troiano et al., “LIM kinase 1 deficient mice have reduced bone mass,” Bone, vol. 52, no. 1, pp. 70–82, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. F. He and Z.-H. Song, “Molecular and cellular changes induced by the activation of CB2 cannabinoid receptors in trabecular meshwork cells,” Molecular Vision, vol. 13, pp. 1348–1356, 2007. View at Google Scholar · View at Scopus
  35. F. Weis, A. Beiras-Fernandez, D. Hauer et al., “Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery,” British Journal of Anaesthesia, vol. 105, no. 2, pp. 139–144, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. S. Rom, V. Zuluaga-Ramirez, H. Dykstra, N. L. Reichenbach, P. Pacher, and Y. Persidsky, “Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier,” The American Journal of Pathology, vol. 183, no. 5, pp. 1548–1558, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus