Evolutionary Insights into IL17A in Lagomorphs

Figure 1

Alignment of IL17A for several mammalian species. GenBank and Ensembl accession numbers are indicated in bold for the retrieved sequences. Positively selected amino acids are boxed (according to [19]). N-glycosylation sites are shaded in light grey and cysteine residues are shaded in dark grey. A black dashed box represents the Agr>Pro mutation between leporids. represents stop codons; − represents indels; ▪ above the numbering represents the sites important for IL17A-IL17Ra interaction. and represent different alleles. Numbering is according to the European rabbit sequence (GenBank accession number XM_002714498.2) and the signal peptide and indels were included in the numbering. Disulfide bonds between side chain cysteines are represented by a light grey dashed line.