Evolutionary Insights into IL17A in Lagomorphs

Table 1

Characterization of the IL17A amino acids differences in the sites important for binding to IL17RA.

Amino acid position	Amino acids
	Leporids				Other mammals
	European rabbit	European brown hare	Brush rabbit	Pygmy rabbit
52	L^#				M^#, S
54	I^#				V^#, S, T
61	S				N, K
70	S				T, L^#
71	D
72	Y
75	R
84	R				P^#, V^#
88	R		P^#		P^#, S
89	E				D
90	R
91	Y				F^#
92	P^#				S
93	S, F^#	F^#	S		F^#, P^#, R
94	V^#
96	W^#				L^#
103	L^#				Q, S, M^#
114	H				P^#, Y, F^#, L^#
115	H
117	N
118	S
122	Q				K
123	Q
124	E
128	L^#
130	R				K
139	F^#
155	P^#				S
156	I^#				M^#
157	I^#				V^#
158	H				S, R, Q, K
159	H				Q, Y, T
160	M^#				I^#, V^#, A, L^#

The amino acid polarity (hydrophilic; ^#hydrophobic) and charge (⁺positive; ⁻negative) are properly annotated. The amino acid present in the human IL17A sequence is underlined. Numbering is according to the European rabbit IL17A sequence.