Downregulation of mPGES-1 Expression via EGR1 Plays an Important Role in Inhibition of Caffeine on PGE₂ Synthesis of HBx(+) Hepatocytes

Figure 2

Effect of caffeine on the expression of COX-2 and mPGES-1 in HBx positive hepatocyte. (a) Representative immunoblots for COX-2, mPGES-1, and β-actin in HL7702 and HL7702-HBx cells. (b) Representative immunoblots for COX-2, mPGES-1, and β-actin in HepG2 and HepG2-HBx cells. The group data represents the mean ± SD (). The densitometry data were normalized to β-actin. Note: , statistically significant difference compared to HL7702 cells (a) or HepG2 cells (b).

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