A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients
Table 5
Association analysis of TRPV5 rs4236480 and subgroups of clinical biochemical data.
TRPV5 rs4236480
Genotype model
Dominant model
Log-additive model
CC
CT
TT
CC
CT+TT
CC-CT-TT
Serum uric acid (%)
>7.2 mg/dL
132 (61.7)
77 (36.0)
5 (2.3)
132 (61.7)
82 (38.3)
214 (96.8)
≤7.2 mg/dL
4 (57.1)
2 (28.6)
1 (14.3)
4 (57.1)
3 (42.9)
7 (3.2)
value
0.3763 (0.3440)
0.8092 (0.5879)
0.2954
OR (95% CI)
1.17 (0.21~6.52)
0.83 (0.18~3.80)
0.60 (0.17~2.14)
Serum calcium (%)
>10.2 mg/dL
1 (33.3)
2 (66.7)
0 (0.0)
1 (33.3)
2 (66.7)
3 (1.4)
≤10.2 mg/dL
132 (61.7)
76 (35.5)
6 (2.8)
132 (61.7)
82 (38.3)
214 (98.6)
value
0.5614
0.3529
0.4734
OR (95% CI)
3.47 (0.31~38.95)
3.22 (0.29~36.07)
2.11 (0.33~13.40)
Serum creatinine (%)
>1.3 mg/dL
29 (56.9)
20 (39.2)
2 (3.9)
29 (56.9)
22 (43.1)
51 (22.2)
≤1.3 mg/dL
115 (64.2)
60 (33.5)
4 (2.2)
115 (64.2)
64 (35.8)
179 (77.8)
value
0.8519
0.8389
0.7234
OR (95% CI)
1.32 (0.69~2.53)
1.36 (0.72~2.57)
1.35 (0.77~2.36)
UCa/UCr1 (%)
≥0.2
33 (63.5)
17 (32.7)
2 (3.8)
33 (63.5)
19 (36.5)
52 (25.5)
<0.2
91 (59.9)
57 (37.5)
4 (2.6)
91 (59.9)
61 (40.1)
152 (74.5)
value
0.8490
0.7703
0.9008
OR (95% CI)
0.82 (0.42~1.61)
0.86 (0.45~1.65)
0.92 (0.52~1.65)
The value corresponding to the likelihood ratio test was obtained from a comparison with the null model and was adjusted for sex and age. 1UCa/UCr, urinary calcium-creatinine ratio. OR: odds ratio; CI: confidence interval.
