Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion

Figure 2

TLR4 gene and protein expression, concentration of TNF-α and IL-1β, and MPO activity in lung tissue or serum during OALT in a rat model. (a–c) TLR4 protein expression in lung tissue. (d) TLR4 mRNA expression in lung tissue. (e-f) TNF-α, IL-1β concentrations in lung tissue. (g-h) TNF-α, IL-1β concentrations in serum. Groups M1, M2, M3, and M4 represented as collecting samples at liver reperfusion after 4 hrs, 8 hrs, 16 hrs, and 24 hrs, respectively. Values are expressed as mean ± SEM. NS: no statistical significance; , , one-way ANOVA with Tukey test.

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