Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion

Figure 4

TLR4/NF-κB P65 pathway was activated in injured lung following OALT. (a) and (b) showed immunofluorescent assay of NF-κB P65 in lung tissue. (c) showed MPO activity in lung tissue. (d) and (e) showed TNF-α and IL-1β concentration in serum and lung tissue, respectively. Groups S, NS, NC, and siRNA were treated with nothing, saline, negative control siRNA, and targeting siRNA, respectively. Values were expressed as mean ± SEM. , , versus Group S, versus Group NC, NS means no significant difference versus Group NC, one-way ANOVA with Tukey test.

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