Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion

Figure 5

TLR4 siRNA reduced lung injury and resulted in an improvement of pulmonary function and rats survival. The effect of TLR4 siRNA on lung pathological change (a and c). Effect of TLR4 siRNA on survival (b). Survival time is calculated from the beginning of liver reperfusion. Results were compared by Kaplan-Meier log rank test and Fisher exact test, . (d) and (e) showed the effect of TLR4 siRNA on pulmonary function evidenced by lung water content and PaO₂. (f) showed correlations between TLR4 protein levels and pathological scores. Groups S, NS, NC, and siRNA were treated with nothing, saline, negative control siRNA, and targeting siRNA, respectively. Values were expressed as mean ± SEM. NS: no statistical significance; , , one-way ANOVA with Tukey test.

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