Mediators of Inflammation

Research Article

Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion

Table 2

Perioperative differences in the expression of TLR4 on PMNs and the serum concentrations of TNF-α and IL-1β between patient groups.


Groups		T₁	T₂	T₃	T₄

ALI ()	TLR4 (MIF)	23.87 ± 13.33	36.59 ± 24.52	43.59 ± 31.05	75.54 ± 34.05
	TNF-α (pg/mL)	73.53 ± 25.72	94.13 ± 40.97	94.80 ± 44.17	289.43 ± 83.04
	IL-1β (pg/mL)	57.52 ± 17.85	62.44 ± 24.09	96.58 ± 41.28	197.01 ± 58.85

Non-ALI ()	TLR4 (MIF)	27.25 ± 11.63	33.05 ± 13.96	38.08 ± 11.42	22.25 ± 7.97
	TNF-α (pg/mL)	129.91 ± 80.55	139.67 ± 83.32	117.79 ± 49.52	163.67 ± 76.35
	IL-1β (pg/mL)	51.94 ± 21.78	44.62 ± 23.40	29.97 ± 22.77	67.63 ± 26.15

MIF: mean fluorescence intensity; T₁: after induction of anesthesia; T₂: 1 hour after anhepatic phase; T₃: 4 hours after neohepatic phase; and T₄: 24 hours after neohepatic phase. Data were expressed as the mean ± SD or median (interquartile range); , versus ; versus non-ALI.