Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway

Figure 5

Kaurenoic acid upregulated the NLRP12 expression in macrophages infected with L. amazonensis. Immunocytochemistry scoring for NLRP12 in macrophages infected with L. amazonensis and treated with kaurenoic acid (50, 70, and 90 μM) for 24 h. Data represent the mean ± SEM of three independent experiments. (Significantly different from infected cells (). (One-way ANOVA followed by Tukey’s test).)