Review Article

In Vivo Experiments with Dental Pulp Stem Cells for Pulp-Dentin Complex Regeneration

Table 1

Description of in vivo experiments with the application of DPSCs for pulp-dentin complex regeneration.

AuthorAnimalEctopic/orthotopicSource of stem cell

Shi et al., 2005 [17]IC miceEctopic (subcutaneous)hDPSCs, SHED, hPDLSCs
Okamoto et al., 2009 [18]IC miceEctopic (subcutaneous)hDPSCs
Alongi et al., 2010 [19]IC miceEctopic (subcutaneous)hDPSCs
Huang et al., 2010 [20]IC miceEctopic (subcutaneous)hDPSCs, SCAP
Wang et al., 2010 [21]IC miceEctopic (subcutaneous)hDPSCs
Galler et al., 2011 [22]IC miceEctopic (subcutaneous)hDPSCs, SHED
Lee et al., 2011 [23]IC miceEctopic (subcutaneous)hDPSCs
Choung et al., 2013 [25]IC miceEctopic (subcutaneous)hDPSCs
Yu et al., 2006 [26]RatsEctopic (renal capsule)hDPSCs
Yu et al., 2007 [27]RatsEctopic (renal capsule)hDPSCs, BMSSCs
Yu et al., 2008 [28]RatsEctopic (renal capsule)hDPSCs
Iohara et al., 2004 [29]DogsOrthotopic (canine)Porcine pulp cells
Iohara et al., 2009 [30]DogsOrthotopic (canine)SP cells from canine pulp
Iohara et al., 2011 [31]DogsOrthotopic (incisor)SP cells from canine pulp
Iohara et al., 2013 [32]DogsOrthotopic (incisor)MDPSCs
Iohara et al., 2014 [33]DogsOrthotopic (incisor)MDPSCs
Zhu et al., 2012 [34]DogsOrthotopic (premolar)cDPSCs
Kodonas et al., 2012 [35]Mini pigsOrthotopic (incisor root, jaw bone)sDPSCs

IC, immunocompromised; hDPSCs, human dental pulp stem cells; SHED, stem cells from human exfoliated deciduous teeth; hPDLSCs, human periodontal ligament stem cells; SCAP, stem cells from apical papilla; BMSSCs, bone marrow stromal stem cells; SP, side population; MDPSCs, DPSC subfraction based on their migratory response to granulocyte-colony stimulating factor; cDPSCs, canine dental pulp stem cells; sDPSCs, swine dental pulp stem cells.