Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology

Figure 2

Lactoferrin mediation of insult-induced inflammation. Insult, defined as infection, trauma, or chronic illness, leads to activation of macrophage and dendritic cells. Activated neutrophils degranulate at the site of injury and release massive amounts of lactoferrin. Lactoferrin, in turn, can either augment low level responses or modulate overaggressive cytokine activity. Both effects serve to control inflammation to assist with tissue repair after insult (modified from [74]).