Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology

Figure 4

Granuloma response to TDM challenge in oral recombinant human lactoferrin-treated mice. Two strains of mice (BALB/c and C57BL/6) were challenged with 25 μg TDM in a water-in-oil emulsion, as described [38, 101]. Human lactoferrin (recombinant, 1 mg) was given orally at 4 and 6 days after TDM challenge. Comparisons are made to naïve mice, and to mice only administered TDM. H&E staining, 100x. Representative sections from mice at 7 days after TDM challenge; per experimental group.