Pegylated Interferon- Modulates Liver Concentrations of Activin-A and Its Related Proteins in Normal Wistar Rat

Table 3

Mean ± SD of immunohistochemistry scores for activin βA-subunit, activin type receptor IIA and IIB, Smad4, Smad7, and follistatin proteins in liver specimens.

	Normal group	Peg-only group	Peg & RBV group	RBV-only group
βA-subunit	215.5 ± 31.2	96.4 ± 23.4^a	111.48 ± 44.3^a	223.9 ± 38.5^b,c
Receptor IIA	283.7 ± 58.7	121.4 ± 29.2^a	135.7 ± 27.6^a	269.2 ± 46.8^a,b
Receptor IIB	332.7 ± 67.6	176.5 ± 32.6^a	202.4 ± 41.8^a,b	294.7 ± 38.6^b,c
Smad4	301.1 ± 26	47.2 ± 20.3^a	66.1 ± 23.9^a	258.7 ± 31.6^a,b,c
Smad7	61 ± 26.7	270.6 ± 68.7^a	267.6 ± 55.3^a	89.6 ± 30.1^b,c
Follistatin	159.4 ± 9.5	373.1 ± 66.8^a	351.8 ± 47.2^a	178.1 ± 43.6^b,c

compared with normal; ^b compared with Peg-only group; and ^c compared with Peg & RBV group.