Mediators of Inflammation / 2015 / Article / Fig 1

Review Article

Cancer Microenvironment and Endoplasmic Reticulum Stress Response

Figure 1

As a consequence of ER stress cells activate signal transduction pathways collectively known as unfolded protein response (UPR). The figure represents the three branches of the UPR and the corresponding UPR sensors (PERK, IRE1, and ATF6).