Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint

Figure 8

Effect of inhibitors of the NFκB signaling pathway on IL-17A-induced IL-6 production by synovial fibroblasts. Synovial fibroblasts were pretreated with the IRAK inhibitor (20 μM), 20 μM LY294002, 1 μM (5z)-7-Oxozeaenol, or 10 μM PS-1145 for 30 min and were then treated with 10 ng/mL IL-17A for 8 h, following which the IL-6 protein levels in the conditioned medium were assayed using ELISA. Results are expressed as means ± SD (); ; .