Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts

<div>Reagents and conditions: (i) (2): Na<sub>2</sub>CO<sub>3</sub>, (<i>R</i>)-methylpiperazine, dioxane, 100°C, 48 h, 91%; (3): Na<sub>2</sub>CO<sub>3</sub>, (<i>S</i>)-methylpiperazine, dioxane, 100°C, 48 h, 88%; (ii): Na<sub>2</sub>CO<sub>3</sub>, 6-chloronicotinonitrile, DMF/dioxane, 180°C, microwave (SM4: 11%, SM3: 16%).</div>

Mediators of Inflammation

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Scheme 1

Scheme 1: Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts 