| Organ involvements | Clinical manifestations | Recommended treatment |
| Mucocutaneous | Oral aphthae, genital ulcers, pseudofolliculitis, papulopustular lesions, erythema nodosum-like lesions, and pathergy reaction | Colchicine, azathioprine, interferon-α, and TNF-α antagonist |
| Eye disease | Recurrent bilateral uveitis (anterior segment, posterior segment, or both), retinal vasculitis, retinal vein occlusion, and optic neuritis | Azathioprine, local or systemic corticosteroids, cyclosporine, infliximab (in combination with azathioprine and corticosteroids), and interferon-α. |
| Gastrointestinal tract | Anorexia, vomiting, dyspepsia, diarrhea, abdominal pain, ulcers, ischemic perforation, thrombosis in the terminal ileum, ileocecal region, and colon | Sulfasalazine, corticosteroids, azathioprine, TNF-α antagonista, and thalidomide. In emergency surgical procedures are required such as ileocolectomy or hemicolectomy |
| Musculoskeletal system | Nonerosive arthritis, nondeforming oligoarthritis, back pain, and sacroiliitis | Colchicine, interferon-α, azathioprine, and TNF-α antagonists |
| Cardiovascular system | Vasculitis, superficial thrombophlebitis, deep vein thrombosis, dural sinus thrombosis, occlusion of suprahepatic veins, pericarditis, myocarditis, endocarditis, intracardiac thrombosis, coronary vasculitis, and ventricular aneurysm | Corticosteroids, azathioprine, cyclosporine, and cyclophosphamide |
| Central nervous system | Severe headache and pyramidal and extrapyramidal symptom (seizures, hemiplegia, and cranial nerve palsies) Central nervous system: focal necrotic cerebral lesions, vascular thrombosis, arterial vasculitis, and aseptic meningoencephalitis Peripheral nervous system: peripheral neuropathies and multiplex mononeuritis | Corticosteroids, interferon-α, azathioprine, cyclophosphamide, methotrexate, and TNF-α antagonists. |
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