Drugs Dose Authors (year) Number of patients Study Effectiveness Azathioprine 2,5 mg/kg/day
Yazici et al. (1990) [34 ] 45 Randomized controlled trial Oral and genital ulcers and eye involvement Colchicine —
Aktulga et al. (1980) [35 ] 35 Double-blind trial Erythema nodosum-like lesions 1-2 mg/day Yurdakul et al. (2001) [36 ] 116 Randomized controlled trial Genital ulcers 1 mg/day Davatchi et al. (2009) [37 ] 169 Randomized controlled trial Genital and oral ulcers and pseudofolliculitis Colchicine versus benzathine penicillin + colchicine —
Çalgüneri et al. (1996) [38 ] 60/94 Open study Oral ulcers and erythema nodosum and genital ulcers Benzathine penicillin versus colchicine versus benzathine penicillin + colchicine Benzathine penicillin 1.2 million units by injection monthly/colchicine 1 mg day/benzathine penicillin + colchicine Al-Waiz et al. (2005) [39 ] 20/21/25 Open study Oral ulcers and erythema nodosum Azithromycin Mumcu et al. (2005) [42 ] 8 Case series Folliculitis and oral ulcers 1500 mg/week for 4 weeks Mumcu et al. (2013) [43 ] 10 Case series Folliculitis and oral ulcers Minocycline — Kaneko et al. (1997) [44 ] — — — Thalidomide 100–300 mg/day Hamuryudan et al. (1998) [45 ] 98 Randomized controlled trial Oral and genital ulcers and folliculitis lesions 50 mg/day
De Wazières et al. (1999) [46 ] 17 Open study Oral and genital ulcers 400 mg/day for 5 days and then 200 mg/day for 4 weeks Gardner-Medwin et al. (1994) [47 ] 23 Open study Oral and genital ulcers 400 mg/day for 5 days and then 200 mg/day
Saylan and Saltik (1982) [48 ] 22 Open study Oral and genital ulcers — Hamza (1986) [49 ] — Open study — Cyclosporine 10 mg/kg/day versus colchicine (1 mg/day) Masuda et al. (1989) [50 ] 96 Randomized controlled trial Oral aphthous, dermal lesion, and genital ulcers 5 mg/kg/day
Assaad-Khalil (1991) [51 ] — Controlled study Orogenital ulcers and skin lesion — Avci et al. (1997) [52 ] — — — Dapsone 100 mg/day Sharquie et al. (2002) [55 ] — Double-blind placebo-controlled trial Orogenital ulcers — Sharquie (1984) [54 ] — Open study — Interferon alpha 2a 6 million units subcutaneously 3 times per week Alpsoy et al. (2002) [57 ] 50 Randomized placebo-controlled and double-blind study Oral ulcers, genital ulcers, and papulopustular lesion 9 million units/day three times a week versus colchicine 1,5 mg/day Boyvat et al. (2000) [58 ] 20/16 Randomized controlled trial — 3 million units subcutaneously daily for 6 months O’Duffy et al. (1998) [59 ] 10 Randomized controlled trial — 6 million units per day 3 times per week for 2 months Georgiou et al. (1998) [60 ] 12 — Oral aphthae, genital ulcers, erythema nodosum, and pseudofolliculitis 3 million units/day in the first week (three times a week), 6 million units/day in the second week (three times a week), 9 million units IU/day in the third week and thereafter (three times a week) Azizlerli et al. (1996) [61 ] 18 — Oral aphthae, genital ulcers, erythema nodosum, and pseudofolliculitis 3 million units three times per week versus 9 million units once a month Alpsoy et al. (1994) [62 ] 14 Randomized controlled trial — 9 million units three times a week for 6 months
Zouboulis et al. (1993) [64 ] 10 — Oral aphthae, genital ulcers, erythema nodosum, pseudofolliculitis 5 million units 3 times a week for 6 weeks followed by 5 million units once a week for 10 weeks Hamuryudan et al. (1994) [63 ] 21 Randomized controlled trial Oral aphthae, genital ulcers, erythema nodosum, and pseudofolliculitis Alemtuzumab —
Perez-Pampin et al. (2013) [67 ] 1 Case report Orogenital aphthosis and erythema nodosum 134 mg Lockwood et al. (2003) [68 ] 18 Open study Orogenital ulcerations Infliximab 5 mg/kg every 8 weeks Olivieri et al. (2009) [74 ] — Case report Mucocutaneous lesions 5 mg/kg for 4th infusion
Haugeberg et al. (2004) [71 ] — Case report Genital ulcers 5 mg/kg every 8 + sulfasalazine Ordahan et al. (2014) [72 ] 1 Case report Oral and genital aphthosis 5 mg/kg every 8 + cyclosporine Olivieri et al. (2008) [73 ] 1 Case report Papulopustulosa, erythema nodosum Etanercept 50/mg/weekly for 12 months [azatioprine + colchicine] Mohammed (2014) [75 ] 15 Open study Mucocutaneous lesions 25 mg twice a week Melikoglu et al. (2005) [76 ] 40 Randomized controlled trial Oral ulcers, papulopustular lesions, and modular lesions 25 mg twice a week Atzeni et al. (2005) [77 ] 1 Case report Genital ulcers Apremilast 30 mg/twice a day Hatemi et al. (2013) [33 ] 55/56 Placebo-controlled double-blind trial Oral and genital ulcers Rebamipide 300 mg/day Matsuda et al. (2003) [56 ] 14/17 Placebo-controlled double-blind trial Oral ulcers Anakinra 100 mg/day Botsios et al. (2008) [19 ] 1 Case report Oral and genital ulcers 1 mg/kg/day + colchicine Bilginer et al. (2010) [79 ] 1 Case report Oral ulcers and erythema nodosum Canakinumab 150 mg every 8 weeks Cantarini et al. (2012) [80 ] 1 Case report Recurrent oral and genital aphthosis, erythema nodosum, and pseudofolliculitis 150 mg every 6 weeks Vitale et al. (2014) [21 ] 3 Case series Mucosal ulcers
