Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2015, Article ID 453020, 13 pages
Research Article

Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms

1Institute for Medical Research, University of Belgrade, 11129 Belgrade, Serbia
2Clinic of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, 11000 Belgrade, Serbia
3Clinic of Hematology, Clinical Center of Serbia, 11000 Belgrade, Serbia
4Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia
5Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA

Received 26 June 2015; Revised 2 September 2015; Accepted 9 September 2015

Academic Editor: Hannes Neuwirt

Copyright © 2015 Vladan P. Čokić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [13 citations]

The following is the list of published articles that have cited the current article.

  • Tijana Subotički, Olivera Mitrović Ajtić, Bojana B. Beleslin-Čokić, Ronny Nienhold, Miloš Diklić, Dragoslava Djikić, Danijela Leković, Tanja Bulat, Dragana Marković, Mirjana Gotić, Constance T. Noguchi, Alan N. Schechter, Radek C. Skoda, and Vladan P. Čokić, “ Angiogenic factors are increased in circulating granulocytes and CD34 + cells of myeloproliferative neoplasms ,” Molecular Carcinogenesis, 2016. View at Publisher · View at Google Scholar
  • Eui Dong Son, Hyoung-June Kim, Kyu Han Kim, Bum Ho Bin, IL-Hong Bae, Kyung-Min Lim, Seok Jong Yu, Eun-Gyung Cho, and Tae Ryong Lee, “ S100A7 (psoriasin) inhibits human epidermal differentiation by enhanced IL-6 secretion through I κ B/NF- κ B signalling ,” Experimental Dermatology, vol. 25, no. 8, pp. 636–641, 2016. View at Publisher · View at Google Scholar
  • Chunjie Yu, Qiong Yang, Yuhong Chen, Demin Wang, Ross Levine, John Crispino, Qiang Wen, and Zan Huang, “Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms,” Cell & Bioscience, vol. 6, no. 1, 2016. View at Publisher · View at Google Scholar
  • Xuewu Liang, Yongxue Huang, Jie Zang, Qianwen Gao, Binghe Wang, Wenfang Xu, and Yingjie Zhang, “Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors,” Bioorganic & Medicinal Chemistry, 2016. View at Publisher · View at Google Scholar
  • Giovanni Barosi, Margherita Massa, Rita Campanelli, Gabriela Fois, Paolo Catarsi, Gianluca Viarengo, Laura Villani, Valentina Poletto, Tiziana Bosoni, Umberto Magrini, Robert P. Gale, and Vittorio Rosti, “Primary myelofibrosis: Older age and high JAK2 V617F allele burden are associated with elevated plasma high-sensitivity C-reactive protein levels and a phenotype of progressive disease,” Leukemia Research, vol. 60, pp. 18–23, 2017. View at Publisher · View at Google Scholar
  • Morten Andersen, Zamra Sajid, Rasmus K. Pedersen, Johanne Gudmand-Hoeyer, Christina Ellervik, Vibe Skov, Lasse Kjær, Niels Pallisgaard, Torben A. Kruse, Mads Thomassen, Jesper Troelsen, Hans Carl Hasselbalch, and Johnny T. Ottesen, “Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development,” Plos One, vol. 12, no. 8, pp. e0183620, 2017. View at Publisher · View at Google Scholar
  • David G. Menter, Scott Kopetz, Ernest Hawk, Anil K. Sood, Jonathan M. Loree, Paolo Gresele, and Kenneth V. Honn, “Platelet “first responders” in wound response, cancer, and metastasis,” Cancer and Metastasis Reviews, 2017. View at Publisher · View at Google Scholar
  • Mengyao Qian, Nana Wu, Liying Ji, and Jianmin Wu, “Significance of combined detection of JAK2V617F, MPL and CALR gene mutations in patients with essential thrombocythemia,” Experimental and Therapeutic Medicine, vol. 13, no. 3, pp. 947–951, 2017. View at Publisher · View at Google Scholar
  • Pablo Angulo, Gaurav Kaushik, Dharmalingam Subramaniam, Prasad Dandawate, Kathleen Neville, Katherine Chastain, and Shrikant Anant, “Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy,” Journal of Hematology & Oncology, vol. 10, no. 1, 2017. View at Publisher · View at Google Scholar
  • Richard K. Lubberich, Thomas Walenda, Tamme W. Goecke, Klaus Strathmann, Susanne Isfort, Tim H. Brümmendorf, Steffen Koschmieder, and Wolfgang Wagner, “Serum of myeloproliferative neoplasms stimulates hematopoietic stem and progenitor cells,” Plos One, vol. 13, no. 5, pp. e0197233, 2018. View at Publisher · View at Google Scholar
  • Pingnan Xiao, Monika Dolinska, Lakshmi Sandhow, Makoto Kondo, Anne-Sofie Johansson, Thibault Bouderlique, Ying Zhao, Xidan Li, Marios Dimitriou, George Z. Rassidakis, Eva Hellström-Lindberg, Nagahiro Minato, Julian Walfridsson, David T. Scadden, Mikael Sigvardsson, and Hong Qian, “ Sipa1 deficiency–induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm ,” Blood Advances, vol. 2, no. 5, pp. 534–548, 2018. View at Publisher · View at Google Scholar
  • Marie Febvre-James, Arnaud Bruyère, Marc Le Vée, and Olivier Fardel, “The jak1/2 inhibitor ruxolitinib reverses interleukin-6-mediated suppression of drug-detoxifying proteins in cultured human hepatocytes s,” Drug Metabolism and Disposition, vol. 46, no. 2, pp. 131–140, 2018. View at Publisher · View at Google Scholar
  • Sidrah Naseem, Tabinda Hussain, and Sobia Manzoor, “Interleukin-6: A promising cytokine to support liver regeneration and adaptive immunity in liver pathologies,” Cytokine & Growth Factor Reviews, 2018. View at Publisher · View at Google Scholar