Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms

Figure 3

IL-6 levels in peripheral blood and bone marrow of MPNs in accordance with JAK2V617F mutant allele burden. (a) IL-6 level in peripheral blood of patients with MPN determined by ELISA (). (b) IL-6 level in bone marrow of patients with MPN determined by immunohistochemistry. (−) no JAK2V617F, (+) heterozygosity, and (++) homozygosity for JAK2V617F mutation (-5, plus control ). Values are mean ± SEM. , regarding MPNs versus Control.

(a) Peripheral blood

(b) Bone marrow