Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms

Table 3

Inflammation signaling related gene expression in CD34⁺ cells of MPNs.

	Genes	Control		ET		PV		PMF
		Mean	SD	Mean	SD	Mean	SD	Mean	SD
IL-6 signaling pathway related gene expression
CEBPB	CCAAT/enhancer binding protein β	−0.3	0.48	−0.5	0.63	−0.3	0.49	−0.1	0.54
FOS	FBJ murine osteosarcoma viral oncogene homolog	2.46	0.87	3.11	1.04	3.74	0.95	2.35	1.38
MAP2K1	Mitogen-activated protein kinase kinase 1	0.49	0.31	0.7	0.15	1.06	0.26	0.19	0.52
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	1.66	0.29	2.02	0.27	2.11	0.34	1.95	0.38
SHC1	Src homology 2 domain cont transforming protein 1	−0.7	0	−0.3	0.54	0.27	0.04	−1.1	0
CSNK2A1	Casein kinase 2, α 1 polypeptide	0.23	0.06	0.23	0.05	0.35	0.51	0.48	0.52
NF-B signaling pathway related gene expression
TNFRSF1A	Tumor necrosis factor receptor superfamily, member 1A	0.58	0.72	1.26	0.86	1.54	0.42	1.64	0.40
NFKBIA	Nuclear factor of kappa light polypept gene enhancer in B-cells inhibitor, α	4.24	0.82	3.70	1.02	3.57	0.91	2.82	1.06
TRADD	TNFRSF1A-associat via death domain	1.30	0.42	1.67	0.22	1.79	0.31	1.38	0.32
NFKB1	Nuclear factor of kappa light polypept gene enhancer in B-cells 1	0.69	0.17	0.28	1.13	1.17	0.24	1.34	1.16
TGF-beta signaling pathway related gene expression
CDKN2B	Cyclin-dependent kinase inhibitor 2B	0.64	1.05	−0.1	1.15	−0.7	1.11	−1.2	1.14
ID3	Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	−2.1	0.48	−2.4	0.65	−3.1	0.14	−3.1	0.37
TFDP1	Transcription factor Dp-1	−0.1	0.49	0.11	0.4	0.61	0.4	0.96	0.69
BMPR2	Bone morphogenetic prot rec type II	1.99	0	1.02	0.89	2.01	0.16
TGFBR1	Transforming growth factor, β recep 1			0.59	0.35	1.04	0.5	0.66	0.14
TGFBR2	Transforming growth factor, β recep II	1.67	0.18			1.55	0.29	1.61	0
IL-10 signaling pathway related gene expression
BLVRA	Biliverdin reductase A	0.70	0.59	1.13	0.45	1.50	0.40	1.31	0.29
IL10RB	Interleukin 10 receptor	0.96	0.31	1.30	0.70	1.15	0.73	0.83	0.75
HMOX1	Heme oxygenase (decycling) 1	1.30	0.44	2.41	0.44	2.32	0.59

Bolded genes represent significantly changed expression versus controls ().