Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma

Figure 1

(a) JAM-1 levels in murine plasma 2 h after experimental blunt chest trauma (TxT), closed traumatic brain injury (TBI), femur fracture including contralateral soft tissue injury (STI + Fx), and combination of injuries (PT) ( = 6–9 per group) compared to sham procedure (). Results are presented as means ± SD; Kruskal-Wallis ANOVA on ranks followed by Dunn’s method; versus sham. (b) Correlation analysis was performed between murine JAM-1 plasma levels and protein concentration in bronchoalveolar lavage (BAL) fluids to assess the impairment of the barrier function 2 h after blunt chest trauma (TxT), TxT in combination with traumatic brain injury (TxT + TBI), TxT combined with femur fracture and contralateral soft tissue injury (TxT + STI + Fx), polytrauma (PT), and sham procedure. Pearson correlation coefficient () of plasma JAM-1 versus BAL protein: with (sham); with (TxT); with (TxT + TBI); with (TxT + STI + Fx); and with (PT). Symbols show values for individual animals; lines represent linear regression for the indicated groups.

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