Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells

Figure 1

Effects of IL-17 on hematopoietic cells. In bone marrow, IL-17 stimulates granulopoiesis and downregulates erythropoiesis through inhibition of late stage erythroid progenitors, CFU-E. At the same time, IL-17 stimulates mobilization of hematopoietic progenitors and mature granulocytes into circulation. Through secondarily induced chemotactic factors, IL-17 stimulates recruitment of granulocytes into a site of inflammation. It also stimulates erythropoiesis in spleen, by mobilizing erythroid progenitors from bone marrow to spleen and stimulating splenic CFU-E differentiation. HSC: hematopoietic stem cell; HPC: hematopoietic progenitor cell; LTRSC: long-term repopulating stem cell; STRSC: short-term repopulating stem cell; CMP: common myeloid progenitor; CFU-GM: colony-forming unit-granulocytic-monocytic; CFU-G: colony-forming unit-granulocytic; BFU-E: burst-forming unit-erythroid; CFU-E: colony-forming unit-erythroid.