Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2015, Article ID 479123, 11 pages
http://dx.doi.org/10.1155/2015/479123
Research Article

MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction

1Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie-Fang Avenue, Wuhan 430022, China
2Department of Cardiology, The Second Hospital of Shandong University, Jinan, Shandong 250033, China
3Department of Cardiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
4Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie-Fang Avenue, Wuhan 430022, China

Received 30 June 2015; Revised 11 September 2015; Accepted 4 October 2015

Academic Editor: Hamid Boulares

Copyright © 2015 Hasahya Tony et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Palojoki, A. Saraste, A. Eriksson et al., “Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 280, no. 6, pp. H2726–H2731, 2001. View at Google Scholar · View at Scopus
  2. A. Diwan, M. Krenz, F. M. Syed et al., “Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice,” The Journal of Clinical Investigation, vol. 117, no. 10, pp. 2825–2833, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Engel, R. Peshock, R. C. Armstong, N. Sivasubramanian, and D. L. Mann, “Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 287, no. 3, pp. H1303–H1311, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. L.-A. Macfarlane and P. R. Murphy, “MicroRNA: biogenesis, function and role in cancer,” Current Genomics, vol. 11, no. 7, pp. 537–561, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Ha and V. N. Kim, “Regulation of microRNA biogenesis,” Nature Reviews Molecular Cell Biology, vol. 15, no. 8, pp. 509–524, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. T. E. Callis, K. Pandya, H. Y. Seok et al., “MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice,” The Journal of Clinical Investigation, vol. 119, no. 9, pp. 2772–2786, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. R. L. Montgomery, T. G. Hullinger, H. M. Semus et al., “Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure,” Circulation, vol. 124, no. 14, pp. 1537–1547, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. E. van Rooij, D. Quiat, B. A. Johnson et al., “A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance,” Developmental Cell, vol. 17, no. 5, pp. 662–673, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Van Rooij, L. B. Sutherland, X. Qi, J. A. Richardson, J. Hill, and E. N. Olson, “Control of stress-dependent cardiac growth and gene expression by a microRNA,” Science, vol. 316, no. 5824, pp. 575–579, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Boštjančič, N. Zidar, D. Štajer, and D. Glavač, “MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction,” Cardiology, vol. 115, no. 3, pp. 163–169, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Satoh, Y. Minami, Y. Takahashi, T. Tabuchi, and M. Nakamura, “Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy,” Journal of Cardiac Failure, vol. 16, no. 5, pp. 404–410, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Ieda, T. Tsuchihashi, K. N. Ivey et al., “Cardiac fibroblasts regulate myocardial proliferation through β1 integrin signaling,” Developmental Cell, vol. 16, no. 2, pp. 233–244, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Aries, P. Paradis, C. Lefebvre, R. J. Schwartz, and M. Nemer, “Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 18, pp. 6975–6980, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. D. W. Huang, B. T. Sherman, and R. A. Lempicki, “Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources,” Nature Protocols, vol. 4, no. 1, pp. 44–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. D. W. Huang, B. T. Sherman, and R. A. Lempicki, “Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists,” Nucleic Acids Research, vol. 37, no. 1, pp. 1–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Nagashima, R. Watanabe, M. Ogawa et al., “Different roles of PPAR-γ activity on physiological and pathological alteration after myocardial ischemia,” Journal of Cardiovascular Pharmacology, vol. 60, no. 2, pp. 158–164, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. M. T. Crow, K. Mani, Y.-J. Nam, and R. N. Kitsis, “The mitochondrial death pathway and cardiac myocyte apoptosis,” Circulation Research, vol. 95, no. 10, pp. 957–970, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Qian, L. W. Van Laake, Y. Huang, S. Liu, M. F. Wendland, and D. Srivastava, “miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes,” Journal of Experimental Medicine, vol. 208, no. 3, pp. 549–560, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. B. A. French and C. M. Kramer, “Mechanisms of postinfarct left ventricular remodeling,” Drug Discovery Today: Disease Mechanisms, vol. 4, no. 3, pp. 185–196, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. M. G. Sutton and N. Sharpe, “Left ventricular remodeling after myocardial infarction: pathophysiology and therapy,” Circulation, vol. 101, no. 25, pp. 2981–2988, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Wang, W. Huang, R. Xu et al., “MicroRNA-24 regulates cardiac fibrosis after myocardial infarction,” Journal of Cellular and Molecular Medicine, vol. 16, no. 9, pp. 2150–2160, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Zhang, Y. Wang, X. Wang et al., “Insulin promotes vascular smooth muscle cell proliferation via microRNA-208-mediated downregulation of p21,” Journal of Hypertension, vol. 29, no. 8, pp. 1560–1568, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Boštjančič, M. Jerše, D. Glavač, and N. Zidar, “miR-1, miR-133a/b, and miR-208a in human fetal hearts correlate to the apoptotic and proliferation markers,” Experimental Biology and Medicine, vol. 240, no. 2, pp. 211–219, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Wang, X. Zhang, X.-P. Ren et al., “MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury,” Circulation, vol. 122, no. 13, pp. 1308–1318, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. A. L. Gartel and A. L. Tyner, “The role of the cyclin-dependent kinase inhibitor p21 in apoptosis,” Molecular Cancer Therapeutics, vol. 1, no. 8, pp. 639–649, 2002. View at Google Scholar · View at Scopus
  26. M. F. van Delft and D. C. S. Huang, “How the Bcl-2 family of proteins interact to regulate apoptosis,” Cell Research, vol. 16, no. 2, pp. 203–213, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. R. F. Place, L.-C. Li, D. Pookot, E. J. Noonan, and R. Dahiya, “MicroRNA-373 induces expression of genes with complementary promoter sequences,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 5, pp. 1608–1613, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Vasudevan, Y. Tong, and J. A. Steitz, “Switching from repression to activation: microRNAs can up-regulate translation,” Science, vol. 318, no. 5858, pp. 1931–1934, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Shan, J. Zheng, R. W. Lambrecht, and H. L. Bonkovsky, “Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes,” Gastroenterology, vol. 133, no. 4, pp. 1166–1174, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. F. See, A. Kompa, J. Martin, D. A. Lewis, and H. Krum, “Fibrosis as a therapeutic target post-myocardial infarction,” Current Pharmaceutical Design, vol. 11, no. 4, pp. 477–487, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. B.-W. Wang, G.-J. Wu, W.-P. Cheng, and K.-G. Shyu, “MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart,” PLoS ONE, vol. 9, no. 1, Article ID e84188, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. K.-G. Shyu, B.-W. Wang, G.-J. Wu, C.-M. Lin, and H. Chang, “Mechanical stretch via transforming growth factor-beta1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts,” European Journal of Heart Failure, vol. 15, no. 1, pp. 36–45, 2013. View at Publisher · View at Google Scholar · View at Scopus