Effect of Helicobacter pylori Eradication on TLR2 and TLR4 Expression in Patients with Gastric Lesions
Table 3
Comparisons of TLR2 and TLR4 mRNA expression levels according to cagA and vacA genotypes of H. pylori in infected patients before and after bacteria eradication treatment.
TLR2
TLR4
Samples (%)
RQ median (range)
value
Samples (%)
RQ median (range)
value
Before treatment
cagA+
11/23 (48.0)
1.32
11/23 (48.0)
1.75
0.689
0.66–23.05
0.518
0.65–11.09
cagA−
12/23 (52.0)
1.41
12/23 (52.0)
1.80
0.71–12.63
0.97–7.17
vacA s1m1
12/25 (48.0)
1.51
12/25 (48.0)
1.97
0.978
0.67–12.63
0.849
0.65–7.17
vacA others
13/25 (52.0)
1.31
13/25 (52.0)
2.02
0.66–23.05
0.97–11.09
After treatment
Eradicated
cagA+
5/11 (46.0)
1.55
5/12 (42.0)
1.61
0.876
0.50–7.21
0.662
1.06–12.01
cagA−
6/11 (54.0)
2.16
7/12 (58.0)
2.69
0.59–43.12
0.64–28.07
vacA s1m1
7/13 (54.0)
0.71
7/13 (54.0)
1.42
0.234
0.34–7.21
0.234
0.64–12.01
vacA others
6/13 (46.0)
2.65
6/13 (46.0)
3.30
0.59–43.12
0.89–28.07
Noneradicated
cagA+
6/12 (50.0)
1.87
6/10 (60.0)
1.99
0.762
1.03–5.61
0.699
0.56–3.92
cagA−
6/12 (50.0)
1.34
4/10 (40.0)
2.59
0.37–6.36
0.82–9.75
vacA s1m1
5/12 (42.0)
1.36
4/11 (36.4)
1.66
0.230
0.65–5.61
0.639
0.56–2.99
vacA others
7/12 (58.0)
1.92
7/11 (63.6)
3.52
0.37–6.36
0.82–9.75
vacAothers (s1m2, s2m2, s1_, s2_, and _m1); value = Mann-Whitney test; .
